from the SBB train station located directly at Zurich airport (close to check-in 2) express trains to St. Gallen are operating every 30 minutes. The time of travel is approx. one hour.
Please find the exact time table here http://fahrplan.sbb.ch/bin/query.exe/en
By car
from Zurich airport head south to A51 towards Bern / Basel / St. Gallen / Zürich;
at the exit 63-Zürich-Nord keep left and follow A1 / A4 towards St. Gallen / Schaffhausen; follow A1 towards St. Gallen and take the exit Appenzell / St.-Gallen Zentrum and there follow the signs Bahnhof-Süd
on the St. Leonhard – Strasse (you will see the main train station on the left hand side) after the supermarket “Migros” and right in front of the “Kantonalbank” turn right at Kornhausstrasse;
there turn the second street right at Teufener Strasse, after approximately 100 meters you will find number 11 on the left hand side;
Public transportation
Axxiome in St. Gallen is located within walking distance (5 min. walk) from the main train station; the exact address is Teufener Strasse 11 in the second floor (please use the “Umantis” bell to ring);
from the main train station use the south exit and cross the Bahnhofplatz – on your right hand side you’ll pass a post office – and go through the “Neumarkt”-Passage;
Turn right on the Teufener Strasse. The number 11 is approx. after 100 meters on the left hand side;
By car:
From the highway (Autobahn) A1 take the exit Appenzell / St.-Gallen Zentrum and there follow the signs Bahnhof-Süd;
on the St. Leonhard – Strasse (you will see the main train station on the left hand side) after the supermarket “Migros” and right in front of the “Kantonalbank” turn right at Kornhausstrasse.
there turn the second street right at Teufener Strasse; after approximately 100 meters you will find number 11 on the left hand side;